The Role of diet in modulating neurodegeneration

Resumen

Gut miroorganisms significantly affect host nutrition, metabolic function, immnue system, and redox levels, and may be modulated by several environmental conditions, including changes in the diet. Accumulated evidence from preclinical and clinical research indicates that gut microbiota, and their associated microbiomes, may influence pathogenic processes and thus the onset and progression of various neurodegenerative diseases via the microbiota-gut-brain axix. In fact, gut dysbiosis Alzheimer's, Parkinson's, and motor neuron diseases such as amyothropic lateral sclerosis. Since the gut microbiota constitute a changeable and experience-dependent ecosystem, the provide potential therapeutic targets that can be modulated as new interventions for dysbiosis-related disorders, including neurodegenerative diseases. This chapter reviews the evidence for diet modulation of gut microbiota and its relevance to brin disorders, exploring in particular the implications for neurodegenerative diseases. Further exploration of diet modulation, acting via parasympathetic, endocrine, immune and circulatory mechanisms to the brain, mey lead to the development of novel therapeutic approaches for a wide range of neurological and psychiatric disorders.