Associations between experimental substance use, FAAH-gene variations, impulsivity and sensation seeking

  1. Evelio Huertas 1
  2. José A. López-Moreno 1
  3. Vanessa Fernández 1
  4. Víctor Echeverry-Alzate 2
  5. Kora-M Bühler 1
  1. 1 Universidad Complutense de Madrid
    info

    Universidad Complutense de Madrid

    Madrid, España

    ROR 02p0gd045

  2. 2 Univerfsidad Complutense de Madrid
Revista:
Psicothema

ISSN: 0214-9915,  1886-144X

Año de publicación: 2019

Volumen: 31

Número: 3

Páginas: 239-245

Tipo: Artículo

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Otras publicaciones en: Psicothema

Resumen

Antecedentes: el uso experimental de sustancias en los jóvenes está relacionada con factores individuales que incluyen rasgos de personalidad, como impulsividad o búsqueda de sensaciones, y variaciones genéticas, como polimorfismos de un solo nucleótido (SNPs) del gen amida hidrolasa de ácidos grasos (FAAH). El objetivo de este estudio es analizar la relación entre estos tres conjuntos de variables. Método: estudiantes universitarios voluntarios (N = 861, 76% mujeres, M = 20,7 años) rellenaron un cuestionario ad hoc de variables relacionadas con el consumo de alcohol, tabaco, cannabis, drogas sintéticas y cocaína. Además, 591 de ellos rellenaron las escalas BIS-11 y SSS-V. Se genotipó a todos ellos en SNP FAAH C385A y su variante proxy rs12075550. Resultados: como se esperaba, la impulsividad y la búsqueda de sensaciones estuvieron asociadas con la mayor parte de las variables relativas al uso experimental de sustancias. Además, encontramos por primera vez evidencia de una asociación entre rs12075550 y algunos de estos fenotipos de consumo. Sin embargo, no encontramos asociaciones significativas entre SNPs e impulsividad o búsqueda de sensaciones. Conclusiones: los resultados resaltan la importancia de tener en cuenta las diferencias genéticas y las de personalidad, junto con los factores contextuales, al analizar el uso de sustancias

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Información de financiación

This work was supported by Fondo de Investigación Sanitaria -Red de Trastornos Adictivos - FEDER (RD16/0017/0008), Ministerio de Economía y Competitividad (PEJ-2014-A-17012-C) and Ministerio de Sanidad, Consumo y Bienestar Social - Plan Nacional sobre Drogas (2018-050).

Financiadores

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